Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
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منابع مشابه
Kinetic analysis of 59Fe movement across the intestinal wall in duodenal rat segments ex vivo.
Duodenal segments from iron-deficient and iron-adequate rats were luminally perfused ex vivo with solutions containing 1, 10, 50, 100, 200 and 500 μmol59Fe/l. When duodenal tissue load and mucosal-to-serosal transport had reached a steady state, perfusion was continued without luminal 59Fe supply. Mobilization of 59Fe from the duodenal tissue into the serosally released absorbate followed first...
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The non-steroidal anti-inflammatory drug diclofenac (DCF) has a high prevalence of intestinal side effects in humans and rats. It has been reported that Mrp2 transporter deficient rats (Mrp2) are more resistant to DCF induced intestinal toxicity. This was explained in vivo by impaired Mrp2-dependent biliary transport of DCF-acylglucuronide (DAG), leading to decreased intestinal exposure to DAG ...
متن کاملIntestinal transport of a tetrapeptide, L-leucylglycylglycylglycine, in rat small intestine in vivo.
1. The intestinal transport mechanism for the tetrapeptide L-leucylglycylglycylglycine, Leu-GlyGly-Gly, and its relation to the transport of free Leu, Leu-Gly and Leu-Gly-Gly were investigated Lt vivo by means of jejunal perfusion in rats. 2. The rates of net Leu absorption from peptides (Leu-Gly and Leu-Gly-Gly-Gly) were significantly greater than those from the free amino acid mixtures when t...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2019
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2019.08.008